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Research Centers and Networks

Collaborative Research Centre 658 (SFB 658) “Elementary Processes in Molecular Switches at Surfaces“

The Collaborative Research Center 658 "Elementary processes in molecular switches at surfaces" (SFB 658) investigates molecular switching processes driven by external excitations in well defined molecular systems at solid surfaces.It focusses on reversible conformational changes of individual molecules and ensembles leading to measurable changes of functional (e.g. optical, electronic or magnetic) properties of the system. (Speaker: Felix von Oppen, Freie Universität Berlin; Partner: Freie Universität Berlin, Fritz-Haber-Institut, Humboldt-Universität Berlin, Paul-Drude-Institut, Universität Postdam, Technische Universität Berlin)

Collaborative Research Center 765 “Multivalency as Chemical Organisation and Action Principle: New Architectures, Functions and Applications”

Multivalent interactions play a major role in the self-assembling of materials, recognition processes and signal transduction in biological systems. The understanding of multivalent interactions and specific development of new multivalent architectures are of great significance for important biological issues, like novel therapeutic concepts for the reduction of inflammation or the prevention of viral or bacterial infections, as well as material science, e.g. for the design of novel surface layers for functional materials.
(Speaker: Rainer Haag, Freie Universität Berlin; Partner: Freie Universität Berlin, Charité - Universitätsmedizin Berlin, Forschungsinstitut für molekulare Pharmakologie, Humboldt-Universität Berlin, Max-Planck-Institut für Kolloid- und Grenzflächenforschung, Technische Universität Berlin, Zuse-Institut Berlin)

Collaborative Research Center 958 "Scaffolding of Membranes - Molecular Mechanisms and Cellular Functions"

Spatiotemporally controlled assembly of protein scaffolds at membranes plays crucial roles in membrane traffic and remodelling, cell signalling, as well as in differentiation and development. The collaborative research centre aims at elucidating the molecular mechanisms by which dynamically organized protein-protein assemblies scaffold cellular membranes and exert cellular functions.
(Speaker: Stephan Sigrist, Freie Universität Berlin; Partner: Freie Universität Berlin, Charité - Universitätsmedizin Berlin, Deutsches Institut für Ernährungsforschung, Forschungsinstitut für molekulare Pharmakologie, Max-Delbrück-Centrum für Molekulare Medizin)

Collaborative Research Center 1078 “Protonation Dynamics in Protein Function”

The central research goal of the SFB 1078 is to identify and understand a new key principal in protein science, namely the control and coordination of complex protein function by protonation dynamics. The goal is to understand, by means of exemplary investigations on the four selected protein systems, the role of protonation dynamics in protein function at a basic physical-chemical level. To achieve this goal, a combination of new biophysical experiments with molecular simulations and quantum-chemical computations is used. Albeit the research program is focused on basic questions, it could inspire new approaches in energy sciences and support the development of new tools in medical sciences and biotechnology.
(Speaker: Holger Dau, Freie Universität Berlin; Partner: Freie Universität Berlin, Charité - Universitätsmedizin Berlin, Forschungsinstitut für molekulare Pharmakologie, Humboldt-Universität Berlin, Technische Universität Berlin)

Collaborative Research Center 1112 “Nanocarriers: Architecture, Transport, and Topical Application of Drugs for Therapeutic Use”

Emphasis of the research program of Collaborative Research Center 1112 (CRC 1112) is the investigation of the fundamentals for treating inflamatory skin diseases by drug loaded nanocarriers. The efficient uptake of drugs into skin is of central importance for the successful topical and local therapy. The goal of CRC 1112 is to concentrate the drugs at the site of action and to minimize side effects on organisms. This requires to optimize the nanoscopic drug carriers as well as the concepts for topical dermatotherapy.
(Speaker: Eckart Rühl, Freie Universität Berlin; Partner: Freie Universität Berlin, Charité - Universitätsmedizin Berlin, Universität Potsdam, Helmholtz-Zentrum Geesthacht)

Other Collaborative Research Projects and Networks

Core Facility BioSupraMol

In recent years the equipment for the analysis of biomacromolecular and supramolecular compounds has been grouped into priority units and networked. Further progress was made in networking the units with external partners at regional and international levels. BioSupraMol emerged from this as an independent Core Facility, consisting at present of five units.

The aim of the Core Facility is, to help scientists and students of the Freie Universität Berlin, in particular those of the Department of Biology, Chemistry, and Pharmacy at the FU Berlin as well as external scientists in solving complex analytical issues by an experienced staff.

HVI Multifunctional Biomaterials for Medicine - VI 423

Piloting approaches in modern medical therapies often require innovative multifunctional biomaterials. Protein-biomaterial surface interactions are widely accepted to critically affect the performance of the materials in a biological environment but are still far from being understood or controlled. In the Helmholtz Virtual Institute (HVI) “Multifunctional Biomaterials for Medicine” the effect of protein adsorption on biophysical properties and the biological response in vitro will be fundamentally studied for novel biomaterials like polyglycerols as nanocarriers or functionalized gelatin for tissue regeneration. (Speaker: Andreas Lendlein, HZG; Partner: Freie Universität Berlin, Helmholtz-Zentrum Berlin, Helmholtz-Zentrum Geesthacht, Universität Freiburg)